Investigation of the effect of Parapoxvirus ovis, Corynebacterium cutis lysate and vitamin c on immunosuppression caused by long-term transport Stress in Morkaraman sheep

Effects of agents on immunosuppression of ewes

  • Kerim Emre Yanar Atatürk University
  • Mustafa Sinan Aktas
Keywords: Transport, stress, Parapoxvirus ovis, Corynebacterium cutis lysate, vitamin C, sheep.


The purpose of the study is to investigate the effectiveness of the inactive Parapoxvirus ovis (iPPVO), Corynebacterium cutis Lysate (CCL) as well as Vitamin C on immunosuppression induced by long-term transport stress in Morkaraman ewes. The study consisted of 4 groups: 1 control, 3 trial groups (iPPVO, CCL and Vit-C) and 8 ewes were allocated into each group (n=32). While levels of cortisol and adrenaline increased (P<0.05) at post-transport (PT), the lowest increase was obtained from the Vit-C group. Lymphocyte counts in iPPVO group increased (P<0.05) at PT. Additionally, ADA activities in the iPPVO, CCL and Vit-C groups increased, while activities of ADA in the control group decreased (P<0.05). A significant positive correlation (r=0.24) (P<0.05) was also obtained between ADA activities and lymphocyte counts. In the control group, Hp levels at 7th days after transport approached levels at Pre-transport (PrT), however, they were similar to PrT at all times in the iPPVO group. In the CCL group, the Hp level at first day after transport (PT1) attained a similar level before transport.

In conclusion, immediately before the transport, administration of Vit-C reduced transport stress more than others. Additionally, it could be suggested that the administration of iPPVO before transport was more effective toward immunosuppression occurring after transport, when lymphocyte counts, ADA activities and Hp levels were taken into consideration.

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